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Nicolas F Wiernsperger

Nicolas F Wiernsperger

University of Lyon, France

Title: Evidences that insulin resistance, core of cardiometabolic diseases, is the primary therapeutic target


Biography: Nicolas F Wiernsperger


Cardiometabolic diseases affect about one third of the worldwide population. Recent years revealed that the core of these different pathologies is insulin resistance. Diminished sensitivity to insulin leads to various metabolic and vascular (both macro- and microvascular) disturbances. Epidemiology and clinical observations show that resistance to this hormone can be seen very early, possibly already in early childhood. It has clearcut impacts on adult health and worsens with aging. However also aging-related diseases such as cognitive dysfunction and related dementias are also associated with resistance to insulin.

The presentation will show the poorly recognized importance of microvascular insulin resistance as well as many aspects of this defect in various tissues. It will also be shown how to detect this parameter easily and early in human beings. Finally suggestions will be made about possible new treatment strategies.